18F-fluorodeoxyglucose Uptake with Expression of Excision Repair Cross-complementary Group 1 and Ribonucleotide Reductase Subunit M1 in Non-small Cell Lung Cancer
نویسندگان
چکیده
Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is widely applied in non‐small cell lung cancer (NSCLC). The standardized uptake value (SUV), a semi‐quantitative index, plays an essential role in NSCLC for diagnosis, staging, and efficacy evaluation. It has been proposed that the SUVmax of tumors may correlate with the presence or absence of chemotherapy resistance‐associated biomarkers based on studies that have displayed a close correlation between SUVmax and the expression levels of excision repair cross‐complementary Group 1 (ERCC1)[1] and Tp53‐induced glycolysis and apoptosis regulator.[2] FDG avidity of NSCLC and ERCC1 and ribonucleotide reductase subunit M1 (RRM1) levels have not been as extensively investigated. Based on these findings, we looked for correlations among metabolic parameters (SUVmax, metabolic tumor volume [MTV], and total lesion glycolysis [TLG]) and ERCC1 and RRM1 expression in patients with NSCLC, to investigate whether FDG uptake reflects the presence or absence of chemoresistance proteins (ERCC1 and RRM1) within tumor cells.
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